Dinitrophenylarsinic acid.



WI'IED STATES ?aIEN'I @FFIQE.

IJUDWIG BENDA, OF FRANKFOBT-ON-THE-MAIN, GERMfLNY, ASSIGNOR TO FAIRB- WERKE VORM. MEISTER. LUCIUS (it BRIINING, 0F HOCHST-ON-THE-MAIN, GER- MANY, A CORPORATION OF GERMANY.

DINITROPHENYLARSENIG ACID.

No Drawing.

To all whom it may concern:

Be it known that I, LUDWIG BENDA, Ph. D., chemist, a citizen of the Republic of Switzerland, residing at Frankfort-on-the- Main, Germany, have invented certain new and useful Improvements in Dinitrophenylarsinic Acid, of which the following is a specification. p

I have found that by starting from diazotized dinitranilin (NH NO NO :1:2:4)

is obtained.

The process can be carried out in a very simple way namely by first diluting with ice the diazo compound, produced by-diazotizing the dinitranilin by means of nitro-syl-sulfuric acid, dissolved in sulfuric acid, and then causing said diazo compound to react with arsenious acid.

The new dinitrophenylarsinic acid is of great Value as parent material for the preparation of arseno compounds to be used for therapeutic purposes.

The following example illustratesmy invention: 18.5 kg. of 1.2.4 dinitranilin are introduced, ata temperature below 25 (3., while stirring, into a mixture of 30 kg. of monohydrate and 23 kg. of a nitrose (a so-. lution of nitrous acid in sulfuric acid), con- Specification of Letters Patent.

Patented Oct. 14, 1913.

Application filed November 6, 1912. Serial No. 725,871.

taining 59 per cent. of nitrosyl sulfuric acid, and the brown solution thus obtained is diluted by adding 250 kg. of ice, whereupon a solution of 25 kg. of sodium arsenite in liters of water is quickly run, while stirring, into this'solution. The reaction occurs at ordinary temperature with intumescence, and in order to complete it, the mass may be gently heat-ed. As soon as the diazo reaction has almost disappeared, a small quantity of animal charcoal is added and the mass is filtered while hot. On addition of common salt, the new compound precipitates from the slightly-colored filtrate in the form of crystals.

The new compound forms needles, very readily soluble in hot water, readily soluble in cold water; it is very readily soluble in alkalis, sodium carbonate and acetate, glacial acetic-acid, methyl alcohol and ethyl alcohol, but is insoluble in ether. Its aqueous solution colors congo-paper violet, and it melts at 199- 200 C.

Having now described my invention, what I claim is:

As a new product, the dinitrophenylar-' sinic acid containing the atom groups N0 N0 and AsO l-l in 1:3:4 position forming needles which are readily soluble in water and alcohol, said acid being readily soluble in alkalis and sodium acetate and melting at 199200 C.

In testimony whereof, Iaifix my signature in presence of two witnesses.

JEAN GRUND, CARL GRUND. 

